1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1-[2-(4-MORPHOLINYL)-2-OXOETHYL]-1H-INDOLE

Name	BML-190
Synonyms	IMMA BML-190 INDOMETHACIN MORPHOLINYLAMIDE 4-((2-(p-chlorobenzoyl)-5-methoxy-2-methyl-3-indolyl)acetyl)-morpholin 1h-indole,1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1-(2-(4-morpholinyl)-2-oxoe BML-190, N-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetyl]morpholine 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETIC ACID, MORPHOLINEAMIDE 1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1-[2-(4-MORPHOLINYL)-2-OXOETHYL]-1H-INDOLE
CAS	2854-32-2

Molecular Formula	C23H23ClN2O4
Molar Mass	426.89
Density	1.31
Melting Point	162.0-163.5 °C
Boling Point	586.7±50.0 °C(Predicted)
Solubility	DMSO: >20mg/mL
Appearance	solid
Color	off-white
pKa	-0.97±0.20(Predicted)
Storage Condition	Sealed in dry,Store in freezer, under -20°C
In vitro study	BML-190 the selectivity of CB2 receptor is 50 times higher than that of CB1 receptor. In HEK-293 cells stably expressing human CB2 receptors, BML-190 enhanced Forskolin-stimulated cAMP accumulation. BML-190 reduces basal levels of inositol phosphate production in cells expressing the CB2 receptor. 10 M BML-190 reduced 38% of the accumulation of inositol phospholipids. BML-190 is an aminoalkylindole. BML-190 can produce at least 15 metabolites. BML-190 reduced LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibited LPS-induced PGE2 production and COX-2 sensing.

WGK Germany

biological activity	BML-190 (IMMA) is a selective reverse agonist of cannabinoid CB2 receptor, Ki is 435 nM, which is 50 times more selective than acting on CB1 receptor.
target	TargetValue CB2 435 nM(Ki)
Target	Value
CB2	435 nM(Ki)
in vitro studies	BML-190 are 50 times more selective for CB2 receptors than for CB1 receptors. In HEK-293 cells stably expressing the human CB2 receptor, the cAMP accumulation stimulated by the BML-190 was enhanced. BML-190 decrease the basal level of inositol phosphate production in cells expressing the CB2 receptor. 10 μM BML-190 reduce 38% inositol phospholipid accumulation. BML-190 is an aminoalkyl indole. BML-190 can produce at least 15 metabolites. BML-190 reduced LPS-induced NO and IL-6 production in a concentration-dependent manner. BML-190 also inhibited LPS-induced PGE2 production and COX-2 induction.

Last Update：2024-04-09 20:52:54

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Product Name: BML-190 Visit Supplier Webpage Request for quotation
CAS: 2854-32-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1-[2-(4-MORPHOLINYL)-2-OXOETHYL]-1H-INDOLE Request for Quotation